Cabergoline in severe ectopic or occult Cushing’s syndrome

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Medical Treatment in Cushings Syndrome: Dopamine Agonists and Cabergoline

Dopamine (DA) is a catecholamine with a wide range of functions and whose five subtype receptors are found in different organs where they exert a mainly inhibitory action. Since this action may also appear in a number of secretory tumors in various locations, DA agonists have elicited some interest as a medical treatment for hypercorticism. Non-iatrogenic Cushing’s syndromes are due in 70% of t...

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Medical Treatment in Cushings Syndrome: Dopamine Agonists and Cabergoline

Dopamine (DA) is a catecholamine with a wide range of functions and whose five subtype receptors are found in different organs where they exert a mainly inhibitory action. Since this action may also appear in a number of secretory tumors in various locations, DA agonists have elicited some interest as a medical treatment for hypercorticism. Non-iatrogenic Cushing’s syndromes are due in 70% of t...

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Neuropsychiatric Disorders in Cushings Syndrome

Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients with active Cushing’s syndrome (CS) are exposed to excessive endogenous glucocorticoid levels. In these patients, psychopathology is often being observed. The most common co-morbid disorder is major depression, but to a lesser extent mania and anxiety disorders have also been reported. A severe clin...

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A case of severe ectopic ACTH syndrome from an occult primary - diagnostic and management dilemmas.

UNLABELLED Resection of primary tumour is the management of choice in patients with ectopic ACTH syndrome. However, tumours may remain unidentified or occult in spite of extensive efforts at trying to locate them. This can, therefore, pose a major management issue as uncontrolled hypercortisolaemia can lead to life-threatening infections. We present the case of a 66-year-old gentleman with ecto...

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Neuropsychiatric Disorders in Cushings Syndrome

Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients with active Cushing’s syndrome (CS) are exposed to excessive endogenous glucocorticoid levels. In these patients, psychopathology is often being observed. The most common co-morbid disorder is major depression, but to a lesser extent mania and anxiety disorders have also been reported. A severe clin...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 2019

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje-18-1014